Backbone dynamics measurements on leukemia inhibitory factor, a rigid four-helical bundle cytokine
نویسندگان
چکیده
منابع مشابه
Leukemia inhibitory factor is an anti-inflammatory and analgesic cytokine.
The mRNA for leukemia inhibitory factor (LIF), a neuroimmune signaling molecule, is elevated during skin inflammation produced by intraplantar injection of complete Freund's adjuvant (CFA). Moreover, although LIF knock-out mice display normal sensitivity to cutaneous mechanical and thermal stimulation compared with wild-type mice, the degree of CFA-induced inflammation in mice lacking LIF is en...
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The FK506-FKBP12 binding-domain of the kinase FRAP (FRB) forms a classic up-down four-helical bundle. The folding pathway of this protein has been investigated using a combination of equilibrium and kinetic studies. The native state of the protein is stable with respect to the unfolded state by some 7 kcal mol(-1) at pH 6.0, 10 degrees C. A kinetic analysis of unfolding and refolding rate const...
متن کاملGPL, a novel cytokine receptor related to GP130 and leukemia inhibitory factor receptor.
We describe a novel cytokine receptor named GP130 Like receptor, or GPL, that displays similarities with the interleukin-6 and interleukin-12 family of signaling receptors. Four different isoforms diverging in their carboxyl terminus were isolated, corresponding to proteins encompassing 560, 610, 626, and 745 amino acids. Sequences included a signal peptide of 32 amino acids, followed by a cyto...
متن کاملLeukemia inhibitory factor, a cytokine at the interface between neurobiology and immunology.
The growing appreciation of the active interface between the immune system and the nervous system includes recognition of the cell surface molecules and the transducing mechanisms that are shared between the two systems. Perhaps even more compelling is the identification of intercellular messengers that mediate active signaling between the two systems. Neurotransmitters and neuropeptides, well ...
متن کاملInvestigation of Leptin, Leukemia Inhibitory Factor (LIF), and IL-6 Serum Levels in Myeloid Leukemia
Background: Leptin has been implicated in the differentiation and proliferation of hematopoietic cells. Leukemia inhibitory factor (LIF) may play an important role, along with Interleukin-6 (IL-6) and granulocyte colony stimulating factor (G- CSF), in the regulation of early hematopoietic stem cells. The aim of the study was to evaluate serum level of leptin, LIF, and IL-6 in myeloid leukemia p...
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ژورنال
عنوان ژورنال: Protein Science
سال: 2008
ISSN: 0961-8368
DOI: 10.1110/ps.9.4.671